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Clinical trial to begin to test Covid vaccine efficacy among children


By PA News

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The new trial will test the immune response in 300 children (PA)

The efficacy of the Oxford/AstraZeneca vaccine in children is set to be tested in a new clinical trial.

Researchers will use 300 volunteers to assess whether the jab – known as the ChAdOx1 nCoV-19 vaccine – will produce a strong immune response in children aged between six and 17.

The Oxford jab is one of three to have been approved for use in adults in the UK, along with those from Pfizer/BioNTech and Moderna.

Andrew Pollard, professor of paediatric infection and immunity, and chief investigator on the Oxford vaccine trial, said: “While most children are relatively unaffected by coronavirus and are unlikely to become unwell with the infection, it is important to establish the safety and immune response to the vaccine in children and young people as some children may benefit from vaccination.

“These new trials will extend our understanding of control of SARS-CoV2 to younger age groups.”

The first vaccinations under the trial will take place this month, with up to 240 children receiving the vaccine and the others receiving a control meningitis jab.

Earlier this week, England’s deputy chief medical officer said “several” trials were under way to develop vaccines that are safe and effective in children.

The role of children in transmission, once they have acquired the infection, is unclear, although there is no clear evidence that they are any more infectious than adults
The Royal College of Paediatrics and Child Health

Professor Jonathan Van-Tam told ITV News: “It is perfectly possible that we will have some licensed children’s vaccines for Covid-19 by the end of the year.”

The Royal College of Paediatrics and Child Health has said there is evidence Covid-19 can cause death and severe illness in children, but that this is rare.

It said: “In children, the evidence is now clear that Covid-19 is associated with a considerably lower burden of morbidity and mortality compared to that seen in the elderly.

“There is also some evidence that children may be less likely to acquire the infection. The role of children in transmission, once they have acquired the infection, is unclear, although there is no clear evidence that they are any more infectious than adults.”

The University of Oxford said theirs was the first trial in the 6-17 age group. It said other trials had begun but only measuring efficacy in those aged 16 and 17.

Rinn Song, paediatrician and clinician-scientist at the Oxford Vaccine Group, said: “The Covid-19 pandemic has had a profound negative impact on the education, social development and emotional well-being of children and adolescents, beyond illness and rare severe disease presentations.

“It is therefore important to collect data on the safety and the immune response to our coronavirus vaccine in these age groups, so that they could potentially benefit from inclusion in vaccination programs in the near future.”

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